abstract：:Role of neurotrophic factors including nerve growth factor (NGF) in the mechanism of overgrowth and hypersensitivity of sensory nerve in atopic dermatitis (AD) has been proposed. Glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophic factors of the nervous systems; however, the role of GDNF in ...

journal_title：Archives of dermatological research

authors： Tokime K,Katoh-Semba R,Yamanaka K,Mizoguchi A,Mizutani H

更新日期：2008-08-01 00:00:00

abstract：:Leprosy is a curable disease with well-defined etiology, but lacks better diagnostic tools, preventive and therapeutic strategies. The continued application of the Ridley-Jopling clinical classification that recognizes the natural diversity of the immune response has provided the basis for understanding leprosy, and t...

journal_title：Archives of dermatological research

authors： Goulart IM,Goulart LR

更新日期：2008-07-01 00:00:00

abstract：:We have observed that lipopolysaccharide (LPS) induces pigmentation in melanocytes and in this study have examined whether these responses are mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway. LPS appears to stimulate the pigmentation of melanocytes and cultured skin. LPS was found to indu...

journal_title：Archives of dermatological research

authors： Ahn JH,Jin SH,Kang HY

更新日期：2008-07-01 00:00:00

abstract：:Solar ultraviolet (UV) irradiation causes damages on human skin and premature skin aging (photoaging). UV-induced reduction of type I collagen in dermis is widely considered primarily induction of wrinkled appearance of photoaging skin. Type I procollagen synthesis is reduced under UV irradiation by blocking transform...

journal_title：Archives of dermatological research

authors： Tanaka H,Yamaba H,Kosugi N,Mizutani H,Nakata S

更新日期：2008-04-01 00:00:00

abstract：:Angiosarcoma, a malignant tumor of vascular endothelial cell origin, is a lethal disease for which complete cure is rarely seen. The objective of this study was to determine the efficiency of photodynamic therapy (PDT) as a new treatment for angiosarcoma. PDT (630 nm, 25 J/cm2) using Photofrin for a mouse angiosarcoma...

journal_title：Archives of dermatological research

authors： Jin I,Yuji M,Yoshinori N,Makoto K,Mikio M

更新日期：2008-04-01 00:00:00

abstract：:Reactive oxygen species (ROS) play important roles in the process of ultraviolet-induced skin damage or photoaging. Although many enzymatic and chemical methods have been developed for evaluating ROS, evaluation methods for ROS generation in living systems are quite limited. Here we propose a unique system to visualiz...

journal_title：Archives of dermatological research

authors： Hakozaki T,Date A,Yoshii T,Toyokuni S,Yasui H,Sakurai H

更新日期：2008-04-01 00:00:00

abstract：:Heparin-binding EGF-like growth factor (HB-EGF) and amphiregulin (AREG) are the members of EGF family that bind to common EGF receptor (EGFR) in the epidermis. However, the role of these two growth factors in epidermal hyperplasia of psoriasis has not been established. On the other hand, CD4+ T cells are responsible f...

journal_title：Archives of dermatological research

authors： Yoshida A,Kanno H,Watabe D,Akasaka T,Sawai T

更新日期：2008-01-01 00:00:00

abstract：:Scleroderma is a chronic fibrosing disease, in which an early inflammatory reaction precedes the fibrotic response. Systematic analysis of the pathways involved in the development of the disease together with information derived from novel animal models have helped to better understand the mechanisms that trigger and ...

journal_title：Archives of dermatological research

authors： Eckes B,Hunzelmann N,Moinzadeh P,Krieg T

更新日期：2007-06-01 00:00:00

abstract：:Congenital atrichia (AUC) is a form of isolated alopecia with an autosomal recessive mode of inheritance. Patients are born with normal hair but this is shed almost completely during the first weeks or months of life and never regrows. In many families the development of papular lesions is noted as an additional pheno...

journal_title：Archives of dermatological research

authors： Betz RC,Indelman M,Pforr J,Schreiner F,Bauer R,Bergman R,Lentze MJ,Nöthen MM,Cichon S,Sprecher E

更新日期：2007-06-01 00:00:00

abstract：:The topical application of a mixture of sugar and povidone--iodine (PI) has been reported to accelerate the healing of cutaneous wounds and ulcers by promoting re-epithelialization and granulation tissue formation as well as having an anti-microbial effect. To clarify the mechanisms accounting for the efficacy of a 70...

journal_title：Archives of dermatological research

authors： Nakao H,Yamazaki M,Tsuboi R,Ogawa H

更新日期：2006-09-01 00:00:00

abstract：:The pathogenetic mechanisms in vitiligo have not been completely clarified. One of the major hypotheses in the pathogenesis of vitiligo is the oxidative stress hypothesis. The active or stable phase of vitiligo is defined on the basis of the progression or appearance of new lesions in the last 3 months and the absence...

journal_title：Archives of dermatological research

authors： Ines D,Sonia B,Riadh BM,Amel el G,Slaheddine M,Hamida T,Hamadi A,Basma H

更新日期：2006-09-01 00:00:00

abstract：:Recently, we discovered that New Zealand rabbits immunized with human type V collagen plus Freund's adjuvant present fibrosis and vasculitis of organs usually affected by systemic sclerosis. In this way, we studied the fibrillogenesis process to identify possible factors involved in altered remodeling observed in this...

journal_title：Archives of dermatological research

authors： Bezerra MC,Teodoro WR,de Oliveira CC,Velosa AP,Ogido LT,Gauditano G,Parra ER,Capelozzi VL,Yoshinari NH

更新日期：2006-07-01 00:00:00

abstract：:Vitiligo is an acquired depigmentary disorder of the skin, characterized by incomplete penetrance, multiple susceptibility loci and genetic heterogeneity. An immunologic hypothesis is currently advanced as a possible pathogenesis of vitiligo. The cytokines have an important role in pathogenesis of autoimmunity in whic...

journal_title：Archives of dermatological research

authors： Yazici AC,Erdal ME,Kaya TI,Ikizoglu G,Savasoglu K,Camdeviren H,Tursen U

更新日期：2006-06-01 00:00:00

abstract：:Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-co...

journal_title：Archives of dermatological research

authors： Kolbe L,Immeyer J,Batzer J,Wensorra U,tom Dieck K,Mundt C,Wolber R,Stäb F,Schönrock U,Ceilley RI,Wenck H

更新日期：2006-06-01 00:00:00

abstract：:Although chemokines are critical elements for the selective attraction and activation of various leukocyte subsets in the inflammatory process, there are few findings concerning T helper (Th) 1 or Th2 chemokines in autoimmune blistering disease (ABD). To determine whether serum levels of chemokines that are preferenti...

journal_title：Archives of dermatological research

authors： Echigo T,Hasegawa M,Shimada Y,Inaoki M,Takehara K,Sato S

更新日期：2006-06-01 00:00:00

abstract：:Because of its easy accessibility, the skin is a very attractive target for gene therapy purposes. To study potential clinical applications in a preclinical setting, appropriate animal models are needed. Pig skin is very similar to human skin, and a variety of human diseases that are potentially amenable to gene thera...

journal_title：Archives of dermatological research

authors： Pfützner W,Joari MR,Foster RA,Vogel JC

更新日期：2006-06-01 00:00:00

abstract：:Solar radiation in the UVB range is absorbed primarily by the epidermal DNA where characteristic photodamage results in altered immune responses and mutagenic lesions. UVB exposure of the skin results in a profound upregulation of the anti-inflammatory cytokine, IL-10 and suppression of contact hypersensitivity (CHS)....

journal_title：Archives of dermatological research

authors： Ma LJ,Guzmán EA,DeGuzman A,Walter B,Muller HK,Walker AM,Owen LB

更新日期：2006-03-01 00:00:00

abstract：:Skin topography and microvasculature undergo characteristic changes with age. Although several non-invasive bioengineering methods are currently available to measure them quantitatively, few publications have referred to their relationship with age in different anatomical sites. This study was carried out to observe t...

journal_title：Archives of dermatological research

authors： Li L,Mac-Mary S,Marsaut D,Sainthillier JM,Nouveau S,Gharbi T,de Lacharriere O,Humbert P

更新日期：2006-03-01 00:00:00

abstract：:We previously showed that the homeodomain protein HOXC13 is involved in the expression control of the early human hair keratin genes hHa5 and hHa2, which contain specific HOXC13 binding sites in their proximal promoters. Hox specificity is generally thought to be enhanced by the interaction with members of the TALE su...

journal_title：Archives of dermatological research

authors： Jave-Suárez LF,Schweizer J

更新日期：2006-02-01 00:00:00

abstract：:The treatment of drug-induced toxic epidermal necrolysis (TEN) remains unsatisfactory. Intravenous immunoglobulins (IVIg) and intravenous cyclosporin A (CsA) have shown some efficacy in short series of patients. We assessed the effects of IVIg and CsA on TEN lesional and apparently uninvolved skin using standard histo...

journal_title：Archives of dermatological research

authors： Paquet P,Jacob E,Damas P,Pirson J,Piérard G

更新日期：2005-12-01 00:00:00

abstract：:Propylene glycol (propane-1,2-diol) is the only diol widely used in dermatology. Pentane-1,5-diol is mainly used as a plasticizer in cellulose products and adhesives, in dental composites and in brake fluid compositions and as a preservative for grain. However, pentane-1,5-diol is also an effective solvent, water-bind...

journal_title：Archives of dermatological research

authors： Faergemann J,Wahlstrand B,Hedner T,Johnsson J,Neubert RH,Nyström L,Maibach H

更新日期：2005-12-01 00:00:00

abstract：:The dermal papilla plays pivotal roles in hair follicle cycle and dermal papilla cells (DPCs) with aggregative behavior have more obviously inductive ability. In the present study, the suppression subtractive hybridization method was employed to identify the differentially expressed genes in dermal papillae cells with...

journal_title：Archives of dermatological research

authors： Zhiqiang S,Jiwen W,Fei H,Weibin Y,Feng Z,Xichuan Y,Chunlan L

更新日期：2005-09-01 00:00:00

abstract：:Histamine is released from mast cells in the skin, causing urticaria and itching. However, little is known about the roles of histamine in development of eczematous lesions in contact dermatitis. Effects of histamine on development of eczematous lesions in contact dermatitis were assessed using histamine-deficient mic...

journal_title：Archives of dermatological research

authors： Seike M,Takata T,Ikeda M,Kodama H,Terui T,Ohtsu H

更新日期：2005-08-01 00:00:00

abstract：:Survivin, a member of the inhibitors of apoptosis protein family, regulates both cellular proliferation and apoptotic cell death. While the human survivin gene is highly expressed in the developing fetus, in adults its expression is restricted to highly proliferating normal tissues and neoplastic tumors tissues. In th...

journal_title：Archives of dermatological research

authors： Vetter CS,Müller-Blech K,Schrama D,Bröcker EB,Becker JC

更新日期：2005-07-01 00:00:00

abstract：:Mast cell chymase is a chymotrypsin-like serine proteinase primarily stored in secretory mast cell granules. Mast cell chymase has various effects on angiotensin, metalloproteases, lipoproteins, procollagen, neuropeptides and cytokines. Recent studies have demonstrated that chymase inhibitors inhibit skin inflammation...

journal_title：Archives of dermatological research

authors： Badertscher K,Brönnimann M,Karlen S,Braathen LR,Yawalkar N

更新日期：2005-04-01 00:00:00

abstract：:Staphylococcus aureus is a common wound-infecting organism which can interact with cells via the extracellular matrix protein fibronectin (FN). The aim of this study was to determine the effect of the FN-binding protein (FnBP) of S. aureus on the behaviour of a human skin keratinocytes cell line (UP). FN-coated plates...

journal_title：Archives of dermatological research

authors： Kintarak S,Nair SP,Speight PM,Whawell SA

更新日期：2004-11-01 00:00:00

abstract：:Despite the fact that polymorphous light eruption (PLE) is the most common photodermatosis, affecting 15% of healthy people in the UK, its pathogeny remains unclear. The condition is more frequent in females and begins often in young adults and in mid-adult life. The mechanism of PLE is under active research as shown ...

journal_title：Archives of dermatological research

authors： Aubin F

更新日期：2004-10-01 00:00:00

abstract：:Ionotrope glutamate receptors of the N-methyl-D-aspartate (NMDA) receptor type are expressed on keratinocytes and influence the intracellular calcium concentration. The importance of NMDA receptors in pathophysiological processes in the skin is, however, still unclear. Epidermal distribution patterns of NMDA receptors...

journal_title：Archives of dermatological research

authors： Fischer M,William T,Helmbold P,Wohlrab J,Marsch WCh

更新日期：2004-09-01 00:00:00

abstract：:The mechanism of action of thalidomide in the treatment of patients with Behçet's disease (BD) is poorly understood. There is some evidence to suggest that certain immunological abnormalities are associated with the pathogenesis of BD. A BD-like mouse model induced by herpes simplex virus (HSV) inoculation shows simil...

journal_title：Archives of dermatological research

authors： Lee ES,Kim YA,Kwon HJ,Bang D,Lee S,Sohn S

更新日期：2004-09-01 00:00:00

abstract：:Besides its role in small-cell carcinoma of the lung, elevated serum levels of neuron-specific enolase (NSE) have recently been reported to be associated with autoimmune rheumatic disorders such as systemic sclerosis. Serum NSE seems to correlate with disease activity as well as Rodnan skin score. The aim of the study...

journal_title：Archives of dermatological research

authors： Breuckmann F,Appelhans C,Bastian A,Stuecker M,Altmeyer P,Kreuter A

更新日期：2004-09-01 00:00:00

abstract：:The safety and efficacy of imiquimod 5% cream is being evaluated for the treatment of dysplastic lesions of the epidermis (actinic keratoses, AK). The objective of this clinical study was to describe the pharmacokinetics and safety of topical imiquimod during multiple dosing of AK subjects. A total of 58 adult subject...

journal_title：Archives of dermatological research

authors： Harrison LI,Skinner SL,Marbury TC,Owens ML,Kurup S,McKane S,Greene RJ

更新日期：2004-06-01 00:00:00

abstract：:The penetration and permeation of the recombinant protein plasminogen activator inhibitor type 2 (PAI-2) in two formulations, one containing a penetration enhancer, into the psoriatic and uninvolved skin of eight patients with plaque-type psoriasis were investigated. Penetration and permeation of PAI-2 were measured b...

journal_title：Archives of dermatological research

authors： Gould AR,Sharp PJ,Smith DR,Stegink AJ,Chase CJ,Kovacs JC,Penglis S,Chatterton BE,Bunn CL

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Human VAT-1 (hVAT-1) is a homologue of the synaptic vesicle membrane protein of Torpedo californica. Its coding gene is located near the BRCA1 locus and thus hVAT-1 may be linked to an inherited predisposition to breast and ovary cancer. However, the hVAT-1 protein expression pattern in normal epith...

journal_title：Archives of dermatological research

authors： Koch J,Foekens J,Timmermans M,Fink W,Wirzbach A,Kramer MD,Schaefer BM

更新日期：2003-09-01 00:00:00

abstract：:Genetic abnormalities for different subtypes of epidermolysis bullosa (EB) have been described. In dominant simplex type EB, mutations of the K5 or K14 gene lead to disruption of basal cells and the formation of bullae. The recessive simplex types include EB with muscular dystrophy due to abnormal plectin, EB without ...

journal_title：Archives of dermatological research

authors： Mitsuhashi Y,Hashimoto I

更新日期：2003-04-01 00:00:00

abstract：:We investigated the effects of 1-4% ointments of metronidazole and tinidazole (derivatives of nitroimidazole) on models of inflammatory dermatitis evoked by antigen, hapten and monoclonal anti-dinitrophenol (DNP) IgE antibody in mice. Metronidazole and tinidazole ointments (1) suppressed the late-phase reaction (LPR) ...

journal_title：Archives of dermatological research

authors： Nishimuta K,Ito Y

更新日期：2003-03-01 00:00:00

abstract：:Sphingosylphosphorylcholine (SPC) has been reported to stimulate wound healing by its potent mitogenic effect. Fibronectin (FN) is a cell-adhesion protein that plays an important role in cell migration and collagen deposition during wound healing. In order to elucidate further the mechanism involved in the accelerated...

journal_title：Archives of dermatological research

authors： Suhr KB,Tsuboi R,Seo EY,Piao YJ,Lee JH,Park JK,Ogawa H

更新日期：2003-01-01 00:00:00

abstract：:Dendritic cell (DC) maturation is essential for the initiation of T-dependent immune responses. Nuclear factor kappa B (NF-kappaB) transcription factors are ubiquitously expressed signalling molecules, known to regulate the transcription of a large number of genes involved in immune responses, including cytokines and ...

journal_title：Archives of dermatological research

authors： Cruz MT,Duarte CB,Gonçalo M,Figueiredo A,Carvalho AP,Lopes MC

更新日期：2002-12-01 00:00:00

abstract：:In 1901, Hans Vörner observed a family with a diffuse non-transgredient palmoplantar keratoderma of autosomal dominant inheritance. Histopathologically, he found epidermolytic hyperkeratosis as a characteristic sign and diagnostic criterion of this disorder. We performed a follow-up study of the family originally seen...

journal_title：Archives of dermatological research

authors： Küster W,Reis A,Hennies HC

更新日期：2002-08-01 00:00:00

abstract：:An increase in phosphodiesterase 4 (PDE4) in blood mononuclear white cells of patients with atopic dermatitis (AD) has been described. This and other skin disorders worsen during stress, during which there are increased circulating levels of adrenaline and glucocorticoids. The aim of this study was to analyse the effe...

journal_title：Archives of dermatological research

authors： Delgado M,Fernández-Alfonso MS,Fuentes A

更新日期：2002-07-01 00:00:00

abstract：:As the main nitrogen source in Malassezia furfur, tryptophan induces the formation of fluorochromes and pigments, which make the yeast less sensitive to UV light. To detect a chemical UV filter, M. furfur (CBS 1878) was incubated at 30 degrees C for 14 days on a pigment-inducing medium and agar extracts were purified ...

journal_title：Archives of dermatological research

authors： Mayser P,Schäfer U,Krämer HJ,Irlinger B,Steglich W

更新日期：2002-05-01 00:00:00